麻豆视频

麻豆视频 特聘研究员、博士生导师。曾任东京大学助理教授和日本学术振兴会外国人特别研究员。主要从事干细胞生物学及其转化医学研究，重点聚焦于诱导性多能干细胞在肝脏疾病治疗中的药物研发与应用。先后主持国家自然科学基金、日本学术振兴会基金等国家级科研项目7项。以第一作者或通讯作者在Hepatology、Developmental Cell、Cell Reports、eBioMedicine等国际权威期刊发表研究论文30余篇，授权国际发明专利2项，申报国际PCT专利4项。

江苏省免疫学会青年工作委员会常务委员

江苏省研究型医院学会玻璃体视网膜疾病专业委员会委员

1.     Yang X*Nie YZ*^{, #} (Lead contact), Lu C, Li Y, Hayashi Y, Plummer R, Luo N, Li Q, Kasai T, Okumura T, Isobe Y, Yamaguchi K, Furukawa Y, Li Y, Taniguchi H#. Human pluripotent stem cell-derived fetal hepatic stellate cells promote vascularization and maturation in liver organoids.Dev Cell. 2025 Sep 29:S1534-5807(25)00540-4.

2.     Li Y, Nie YZ^#, Taniguchi H. Protocol for generating liver organoids containing Kupffer cells using human iPSCs. STAR Protoc. 2025 Oct 10;6(4):104138.

3.     Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie YZ, Taniguchi H, Miyake K. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025 Mar 3;222(3):e20230647.

4.     Li Y*, Nie YZ*^{, #} (Lead contact), Yang X, Liu Y, Deng X, Hayashi Y, Plummer R, Li Q, Luo N, Kasai T, Okumura T, Kamishibahara Y, Komoto T, Ohkuma T, Okamoto S, Isobe Y, Yamaguchi K, Furukawa Y, Taniguchi H*. Integration of Kupffer cells into human iPSC-derived liver organoids for modeling liver dysfunction in sepsis.Cell Rep. 2024 Mar 26;43(3):113918.

5.     Tadokoro T, Murata S, Kato M, Ueno Y, Tsuchida T, Okumura A, Kuse Y, Konno T, Uchida Y, Yamakawa Y, Zushi M, Yajima M, Kobayashi T, Hasegawa S, Kawakatsu-Hatada Y, Hayashi Y, Osakabe S, Maeda T, Kimura K, Mori A, Tanaka M, Kamishibahara Y, Matsuo M, Nie YZ, Okamoto S, Oba T, Tanimizu N, Taniguchi H.H uman iPSC-liver organoid transplantation reduces fibrosis through immunomodulation. Sci Transl Med. 2024 Jul 24;16(757):eadg0338.

6.     Ma M, Ge JY, Nie YZ, Li YM, Zheng YW. Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells.Front Biosci (Landmark Ed). 2024Jan 19;29(1):34.

7.     Nie YZ, Zheng YW, Taniguchi H.Improving the repopulation capacity of elderly human hepatocytes by decoding aging-associated hepatocyte plasticity. Hepatology. 2022 Oct;76(4):1030-1045.

8.     Li Y, Yang X, Plummer R, Hayashi Y, Deng XS, Nie YZ^#, Taniguchi H^#.Human Pluripotent Stem Cell-Derived Hepatocyte-Like Cells and Organoids for Liver Disease and Therapy.Int J Mol Sci. 2021 Sep 28;22(19):10471.

9.     Qiu R, Murata S, Cheng C, Mori A, Nie YZ, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment. Cancers (Basel). 2021 Aug 8;13(16):3997.

10.  Nie YZ, Zheng YW, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H. Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine. 2018 35:114-123.

11.  Nie, YZ, Zheng YW, Ogawa M, Miyagi E, Taniguchi H. Human liver organoids generated from single donor derived multiple cells rescues mice from acute liver failure. Stem cell Res & Ther. Vol.9, No.5, pp.1-12, 2018.

12.  Zhang RR, Zheng YW, Li B,Nie YZ, Ueno Y, Tsuchida T, Taniguchi H.Hepatic stem cells with self-renewal and liver repopulation potential are harbored in CDCP1-positive subpopulations of human fetal liver cells. Stem cell Res & Ther. Vol.9, No.29, pp.1-14, 2018.

13.  Guan HB*, Nie YZ*, Zheng YW, Takiguchi K, Yu HW, Zhang RR, Li B, Tsuchida T, Taniguchi H. Acyclic retinoid 

      induces differentiation and apoptosis of murine hepatic stem cells. Stem Cell Res & Ther. Vol.6, No.51, pp.1-11, 2015.

14.  Zhao S, Chu Z, Blanco VM, Nie YZ, Hou Y, Qi X. SapC–DOPS Nanovesicles as Targeted Therapy for Lung Cancer. Mol Cancer Ther. Vol.14, No.2, pp. 491-498, 2015

15.  Tang RJ, Shen SN, Zhao XY, Nie YZ, Xu YJ, Ren J, Lv MM, Hou YY, Wang TT. Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. Stem Cell Res & Ther. Vol.6, No.71, pp.1-11, 2015.

16.  Zhang RR, Zheng YW, Li B, Tsuchida T, Ueno Y, Nie YZ, Taniguchi H. Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities. Stem Cell Res & Ther. Vol.6, No.49, pp.1-12, 2015

17.  Ren J*, Nie YZ*, Lv M, Shen S, Tang R, Xu Y, Hou Y, Zhao S, Wang T. Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17. Cell Mol Immunol. Vol.12, No.6, pp.768-776, 2015. (* equally contributed)

18.  Xie J, Liu M, Li Y, Nie YZ, Mi Q, Zhao S. Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression. Cell Mol Immunol. Vol.11, No.5, pp.495-502, 2014.

19.  Zheng YW*, Nie YZ*, Tsuchida T, Zhang RR, Aoki K, Sekine K, Ogawa M, Takebe T, Ueno Y, Sakakibara H, Hirahara F, Taniguchi H. Evidence of a Sophisticatedly Heterogeneous Population of Human Umbilical Vein Endothelial Cells. Transplant Proc. Vol.46, No.4, pp.1251-1253, 2014. (* equally contributed)

20.  Nie YZ, Du L, Mou Y, Xu Z, Weng L, Du Y, Zhu Y, Hou Y, Wang T. Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation. BMC Cancer. Vol.13, No.582, pp.1-11, 2013.

21.  Nie YZ, Chen Y, Mou Y, Weng L, Xu Z, Du Y, Wang W, Hou Y, Wang T. Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma. PLoS One. Vol.8, No.11, e72411, 2013. 

22.  Zheng YW*, Nie YZ*, Taniguchi H. Cellular reprogramming and hepatocellular carcinoma development. World J 

      Gastroenterol. Vol.2119, No.47, pp.8850-8860, 2013. (* equally contributed)

23.  Zhao S, Wang H, Nie YZ, Mi Q, Chen X, Hou Y. Midkine upregulates MICAB expression in human gastric cancer cells and decreases natural killer cell cytotoxicity. Cancer Immunol Immunother. Vol.61, No.10, pp.1745-1753, 2012.

24.  Zhao G, Nie YZ, Lv M, He L, Wang T, Hou Y. ERβ-mediated estradiol enhances epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine. Mol Endocrinol. Vol.26, No.8, pp.1304-1315, 2012.

25.  Wang T, Nie YZ, Zhao S, Han Y, Du Y, Hou Y. Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells. Bioelectromagnetics. Vol.32, No.6, pp.443-452, 2011.

26.  Wang T, Lv M, Qian Q, Nie YZ, Yu L, Hou Y. Increased frequencies of T helper type 17 cells in tuberculous pleural effusion. Tuberculosis (Edinb). Vol.91, No.3, pp.231-237, 2011.

(* equal contribution; ^# corresponding author))

国家自然科学基金青年项目(主持)

麻豆视频 队伍建设启动经费 (主持)

国家重点研发计划“病原学与防疫技术体系研究”重点专项（骨干成员）

日本学术振兴会外国人特别研究员

江苏省高等学校科学技术研究成果奖，二等奖

日本文部科学省留学生全额奖学金