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刘效磊，麻豆视频 准聘助理教授，特聘研究员，博士生导师。 刘效磊博士毕业于天津医科大学，先后在中国医学科学院血液病医院（血液学研究所）和宾夕法尼亚大学麻豆视频 进行博士后研究。以第一作者在JCI, PNAS 等知名期刊发表多篇论文。2025年8月加入麻豆视频 。课题组主要关注血液系统干细胞生物学，利用细胞和动物模型结合多组学以及高通量筛选等技术研究正常造血干细胞（HSC）和白血病干细胞（LIC）的自我更新与分化调控机制；血液系统疾病包括克隆性造血（CHIP）、骨髓增生异常综合征（MDS）以及急性髓性白血病（AML）的发病机制和靶向治疗。 欢迎优秀硕士博士研究生，博士后和访问学者加入课题组！ 1. Blake Hernandez, Piotr Tetlak, Ana Domingo-Muelas, Hiroki Akizawa, Robin M Skory, Goli Ardestani, Mate Biro, Xiaolei Liu, Stephanie Bissiere, Denny Sakkas, Nicolas Plachta. Actin organizes chromosomes and microtubules to ensure mitotic fidelity in the preimplantation embryo. Science, 2025 May 22;388(6749): eads1234. doi: 10.1126/science.ads1234. Epub 2025 May 22. 2. Huan Li, Srinivas Chatla, Xiaolei Liu, Zhen Tian, Umeshkumar Vekariya, Peng Wang, Dongwook Kim, Stacia Octaviani, Zhaorui Lian, George Morton, Zijie Feng, Dan Yang, Katherine Sullivan-Reed, Wayne Childers, Xiang Yu, Kumaraswamy Naidu Chitrala, Jozef Madzo, Tomasz Skorski, Jian Huang. ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination. Cancer Lett. 2025 Mar 31:613:217505. doi: 10.1016/j.canlet.2025.217505. Epub 2025 Jan 31. 3. Xiaolei Liu, Sudish Devadiga, Robert Stanley, Michael Mallory, Oz Pomp, Adam Moverley, Chenchen Li, Nico Skuli, Martin Carroll, Jian Huang, Kristen Lynch, Omar Abdel-Wahab, Peter S Klein. A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. Journal of Clinical Investigation. 2024, May 7;134(12):e175619. doi: 10.1172/JCI175619. 4. Xiaolei Liu#, William D Jones#, Mathieu Quesnel-Vallières, Sudhish A Devadiga, Kristin Lorent, Alexander J Valvezan, Rebecca L Myers, Ning Li, Christopher J Lengner, Yoseph Barash, Michael Pack, Peter S Klein.The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. J Dev Biol. 2023 Jun 29;11(3):29. doi: 10.3390/jdb11030029. (# contribute equally). 5. Jianzhong Han#, Xiaolei Liu#, Yue Xu, Qian Wang, Li Li, Kehe Du, Chenchen Li, Hongjun Liu, Yu Chen, Jian Huang. Characterization of HZ0412a, a novel potent humanized anti-IL-6 receptor antibody that blocks IL-6R binding to gp130. Antib Ther. 2023 May 11;6(2):119-126. (# contribute equally). 6. Yinghui Li, Mei He, Wenshan Zhang, Wei Liu, Hui Xu, Ming Yang, Hexiao Zhang, Haiwei Liang, Wenjing Li, Zhaozhao Wu, Weichao Fu, Shiqi Xu, Xiaolei Liu, Sibin Fan, Liwei Zhou, Chaoqun Wang, Lele Zhang, Yafang Li, Jiali Gu, Jingjing Yin, Yiran Zhang, Yonghui Xia, Xuemei Mao, Tao Cheng, Jun Shi, Yanan Du & Yingdai Gao. Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic microniche. Nat Commun, 2023 Apr 18;14(1):2207. doi: 10.1038/s41467-023-37954-3. 7. Xiaolei Liu#, Li Li#, Qian Wang, Fengchao Jiang, Pei Zhang, Fei Guo, Hongjun Liu, Jian Huang. A novel humanized anti-Interleukin-6 antibody HZ0408b with anti-rheumatoid arthritis therapeutic potential. Front Immunol. 2022 Jan 19;12:816646. doi: 10.3389/fimmu. 2021.816646. (# contribute equally). 8. Xiaolei Liu#, Anurag Verma#, Gustavo Garcia Jr, Holly Ramage, Anastasia Lucas, Rebecca L Myers, Jacob J Michaelson, William Coryell, Arvind Kumar, Alexander W Charney, Marcelo G Kazanietz, Daniel J Rader, Marylyn D Ritchie, Wade H Berrettini, David C Schultz, Sara Cherry, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Peter S Klein. Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. PNAS, 2021 Oct 19;118(42):e2113401118. doi: 10.1073/pnas.2113401118. (# contribute equally). 9. Yinghui Li, Wenshan Zhang, Yu Zhang, Yahui Ding, Ming Yang, Mei He, Xiaolei Liu, Jiali Gu, Shiqi Xu, Zhiwei Feng, Yafang Li, Jingjing Yin, Huier Gao, Henan Song, Hui Xu, Chaoqun Wang, Qing Ji, Shihui Ma, Wanzhu Yang, Weiping Yuan, Xiang-Qun Xie, Tao Cheng, Yingdai Gao. Enhanced self-renewal of human long-term hematopoietic stem cells by a sulfamoyl benzoate derivative targeting p18INK4C. Blood Adv. 2021 Sep 14;5(17):3362-3372. 10. Xiaolei Liu, Peter S Klein. Leukemic Stem Cell Culture in Cytokine-Free Medium. Methods Mol Biol. 2021; 2185: 259-265.doi: 10.1007/978-1-0716-0810-4_15. 11. Yinghui Li, Yafang Li, Jingjing Yin, Chaoqun Wang Ming Yang, Jiali Gu, Mei He, Hui Xu, Weichao Fu, Wenshan Zhang, Yongxin Ru, Xiaolei Liu, Ying Li, Yue Xin, Huier Gao, Xiangqun Xie, Yingdai Gao. A mitophagy inhibitor targeting p62 attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Lett. 2021 Jul 10;510:24-36. doi: 10.1016/j.canlet.2021.04.003. 12. Xiaolei Liu, Peter S Klein. Glycogen synthase kinase-3 and alternative splicing. Wiley Interdiscip Rev RNA. 2018 Oct;1864(10):3368-3377. doi:10.1016/j. bbadis.2018.07.023. 13. Dheeraj Bhavanasi, Kwun Wah Wen, Xiaolei Liu, Francois Vergez, Gwenn Danet-Desnoyers, Martin Carroll, Jian Huang, Peter S Klein. Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells. Blood Cancer J. 2017 Nov 30; 7(12):636. doi: 10.1038/s41408-017-0003-1. 14. Xiaolei Liu, Yanmei Niu, Hairui Yuan, Jian Huang, Li Fu. AMPK binds to Sestrins and mediates the effect of exercise to increase insulin sensitivity through autophagy. Metabolism. 2015 Jun;64(6):658-65. doi: 10.1016/j.metabol.2015.01.015. 15. Xiaolei Liu, Hairui Yuan, Yanmei Niu, Wenyan Niu, Li Fu. The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice. Biochim Biophys Acta Mol Basis Dis. 2012 Nov;1822(11):1716-26. doi: 10.1016/j.bbadis.2012.07.008. 1.Rising Star Award, University of Pennsylvania, June, 2024. 2.RNA travel grant, Penn Institute for RNA Innovation, University of Pennsylvania, March, 2023. 3.Zhang Xijun Award, Chinese Association for Physiological Sciences, 2013. |
